物质信息
ID:716822
名称和标识
IUPAC传统名
acetylacetone
别名
AcetylacetoneAcAc2,4-戊烷二酮2,4-Pentanedione
IUPAC标准名
pentane-2,4-dione
化合物性质
安全信息
GHS危险声明
H226-H302
安全公开号
21-23-24/25
欧盟危险性物质标志
有害性 (X)TSCA收录
是
GHS警示性声明
P210-P241-P280-P303+P361+P353-P403+P235-P501A
危险公开号
10-22
联合国危险货物等级
3
联合国危险货物包装类别(PG)
III
RTECS编号
SA1925000
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
联合国危险货物编号
UN2310
产品相关信息
纯度
99%
理化性质
沸点
140-141°C
密度
0.973
闪点
34°C(93°F)
折射率
1.4520
熔点
-23°C
描述信息
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分子图谱
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参考文献
• A simple procedure for the synthesis of methyl ketones involves alkylation at the 3-position with an alkyl halide using K2CO3 in EtOH, with in situ acetyl cleavage: Org. Synth. Coll., 5, 767 (1973). Knoevenagel condensation with aldehydes in THF in the presence of K2CO3 also occurs with acetyl cleavage, providing a simple route to alkenyl ketones: Chem. Lett., 1325 (1978). With K2CO3 and TBAB, selective one-pot monoalkylation or dialkylation with different alkyl groups can be achieved: Synthesis, 688 (1989). 3-Arylation with aryl bromides takes place in the presence of Cu(I) or Cu(II) salts in DMF: Chem. Lett., 597 (1982); Org. Synth. Coll., 6, 36 (1988).
• Strong bases, e.g. NaNH2, form the dianion which reacts with electrophiles, e.g. alkyl halides, esters, acyl halides, Michael acceptors, etc., at the less-stabilized terminal carbon: J. Org. Chem., 26, 1716 (1961); Tetrahedron Lett., 357 (1970); J. Org. Chem., 39, 2289 (1974); Org. Synth. Coll., 5, 848 (1973). For arylation at the 1-position, see Diphenyliodonium chloride, A15149. For reviews of dimetallation, see: Org. React., 17, 155 (1969); Synthesis, 509 (1977).