物质信息
ID:716642
名称和标识
IUPAC标准名
2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC传统名
N-hydroxyphthalimide
别名
N-HydroxyphthalimideN-羟基邻苯二甲酰亚胺NHPI
化合物性质
理化性质
熔点
ca 233°C dec.
安全信息
GHS警示性声明
P261-P305+P351+P338-P302+P352-P321-P405-P501A
危险公开号
36/37/38
RTECS编号
TI5200000
TSCA收录
是
安全公开号
26-37
GHS危险声明
H315-H319-H335
欧盟危险性物质标志
刺激性 (Xi)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
产品相关信息
纯度
98+%
描述信息
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分子图谱
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参考文献
• Efficient electron carrier for electrochemical oxidation of alcohols: J. Chem. Soc., Chem. Commun., 479 (1983). Has also been found to be an efficient catalyst for non-electrochemical oxidation of benzylic groups in benzonitrile solution with atmospheric pressure oxygen: J. Org. Chem., 60, 3934 (1995). The method can be extended to alkanes by the use of a catalyst such as 0.5-1 mol% Co(acac)2. Thus cyclohexane is oxidized to cyclohexanone and adipic acid; adamantane gives mainly 1-adamantanol with minor amounts of 2-adamantanone and 1,3-adamantanediol: J. Org. Chem., 61, 4520 (1996). Under similar conditions alkynes can be oxygenated to ɑ?-acetylenic ketones in good yields: Chem. Commun., 2037 (1998).
• Additive in the carbodiimide method of peptide coupling, leading to decreased racemization: J. Am. Chem. Soc., 89, 7151 (1967). For alternative reagents, see N,N'-Dicyclohexylcarbodiimide, A10973, and Appendix 6.
• O-Alkylation followed by hydrazinolysis gives O-alkylhydroxylamines: Bull. Soc. Chim. Fr., 833 (1976). Copper-promoted coupling with arylboronic acids, followed by hydrazinolysis, affords O-arylhydroxylamines: Org. Lett., 3, 139 (2001).