物质信息
ID:715132
名称和标识
IUPAC标准名
methanesulfonylbenzene
IUPAC传统名
sulfone, phenyl, methyl-
别名
甲基苯基砜Methyl phenyl sulfone
化合物性质
产品相关信息
纯度
98+%
安全信息
GHS危险声明
H302
GHS警示性声明
P264-P270-P301+P312-P330-P501A
TSCA收录
否
危险公开号
22
RTECS编号
WR6800000
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
欧盟危险性物质标志
有害性 (X)安全公开号
36
理化性质
熔点
85-88°C
描述信息
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分子图谱
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参考文献
• Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ?-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl phenyl sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ?-keto sulfones: J. Org. Chem., 53, 906 (1988).
• Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990).