物质信息
ID:714479
名称和标识
IUPAC标准名
2,2,2-trifluoroethan-1-ol
IUPAC传统名
trifluoroethanol
别名
2,2,2-三氟乙醇Trifluoroethyl alcohol2,2,2-Trifluoroethanol
化合物性质
理化性质
沸点
74-75°C
熔点
-44°C
闪点
29°C(84°F)
密度
1.391
折射率
1.2900
安全信息
联合国危险货物等级
3
GHS危险声明
H301-H311-H331-H315-H335-H318-H226
欧盟危险性物质标志
有害性 (X)联合国危险货物包装类别(PG)
III
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
GHS警示性声明
P210-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
危险公开号
10-20/21/22-37/38-41
RTECS编号
KM5250000
联合国危险货物编号
UN1992
TSCA收录
是
安全公开号
9-23-26-36/37/39-60
产品相关信息
纯度
99+%
描述信息
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分子图谱
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参考文献
• The stereodirecting effect of the MEM group (see 2-Methoxyethoxymethyl chloride, L01050) has been exploited by Percy et al in the formation of a new fluorine-containing acyl anion equivalent: Tetrahedron, 51, 9201 (1995):
• Effective solvent for uncatalyzed epoxidations of alkenes with hydrogen peroxide (caution! 60%): Synlett, 248 (2001). For a review of fluorinated alcohols as solvents for selective and clean reactions, see: Synlett, 18 (2004).
• Useful ionizing solvent, see: Tetrahedron Lett., 2335 (1974), and references therein. Good solvent for oligopeptides with potential as a cosolvent along with proton acceptors such as DMF for peptide coupling reactions: Tetrahedron Lett., 33, 7007 (1992). Compare 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747.
• Claisen or Wittig rearrangements of the derived difluoroallyl alcohols can be used in routes to molecules containing a CF2 group: Tetrahedron, 51, 11327 (1995); J. Org. Chem., 61, 166 (1996), or to monofluorinated vinylic compounds: Tetrahedron Lett., 37, 5183 (1996).
• Trifluoroethyl esters have also found use as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).
• Reacts with triphenylphosphine dibromide to give the bis(trifluoroethoxy)phosphorane, which converts alcohols to trifluoroethyl ethers, carboxylic acids to trifluoroethyl esters and aldehydes to bis(trifluoroethyl) acetals: J. Org. Chem., 45, 5052 (1980).