物质信息

ID:674

名称和标识
商标名
AloprogenHaloprogin [USAN:INN:JAN]Haloprogina [INN-Spanish]Haloprogine [INN-French]Haloproginum [INN-Latin]MycandenMycilanHalotexPolik
IUPAC传统名
haloprogin
IUPAC标准名
1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
别名
Haloprogin
数据登录号
CAS号
PubChem SID
PubChem CID
化合物性质
理化性质
疏水性(logP)
5.3
描述信息
Drug Groups
approved
Description
Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function.
Indication
Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
Pharmacology
Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Affected Organisms
Dermatophytic fungi including Trichophyton, Microsporum and Epidermophyton
References
• Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50. [Pubmed]
• Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. [Pubmed]
External Links
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参考文献
• Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50. Pubmed
• Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. Pubmed