物质信息
ID:503
名称和标识
IUPAC标准名
(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
IUPAC传统名
triamcinolone
别名
TriamcinoloneFluoxyprednisoloneFluoxiprednisoloneTriamcinolonum [INN]Triamcinolone hexacetonideTiamcinolonum [INN-Latin]TriamcinaloneTriamcinolone acetonideTriamcinolone diacetateTriamcinolona [INN-Spanish]
商标名
KenalogAdcortylAristocortAristocort AAristogelDelphicortFlutexOrionSk-TriamcinoloneTriamcetTriatexTristojectAristospanCinolone-TNasacortNasacort HfaOmcilonOraloneTriamcinolonTridermAristocort TabletsKenalog-40LedercortNasacort AqRodinoloneTriacortTriam-TablinenCelesteCinoloneKenacortKenacort-AKenacort-AgTriamcinlonVetalogVolonTriloneAzmacortKenalog-10OmicilonPolcortolonTriacetVolon AFougeraKenalog in OrabaseKenalog-HOracortTri-NasalTricortaleTrymex
化合物性质
理化性质
疏水性(logP)
0.2
溶解度
80 mg/L
描述信息
Drug Groups
approved
Description
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Indication
For the treatment of perennial and seasonal allergic rhinitis.
Pharmacology
Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.
Toxicity
LD50=>500mg/kg (in rats)
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
Absorption
Rapid absorption following oral administration
Half Life
88 minutes
Protein Binding
68%
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