物质信息
ID:449799
名称和标识
别名
trisoralentrimethylpsoralenDermetrixLevrison4,5',8-TrimethylpsoralenTrioxysalenTripsos
IUPAC标准名
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
IUPAC传统名
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Medicinal pigmentation agent
Dermatological agent
Tool used in molecular biology for labelling and isolating nascent DNA fragments
Radiosensitizer
Photosensitiser
生物来源
Phytotoxic metab. of pink rot disease, produced by Sclerotinia sclerotiorum
药理学性质
生物活性机理
Action depends on the presence of functional melanocytes and their proliferation by photoactivated drug
Exact mechanism with epidermal melanocytes and keratinocytes unknown.
Conjugates and forms covalent-bonds with DNA which leads to the formation of both monofunctional and bifunctional adducts upon photoactivation
描述信息
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分子图谱
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参考文献
• Thompson, H.J. et al., J. Chromatogr., 1984, 314, 323, (hplc)
• Hassan, M.A., Anal. Profiles Drug Subst., 1981, 10, 705, (rev)
• Elgamal, M.H.A. et al., Phytochemistry, 1979, 18, 139, (cmr)
• Gencheva, M. et al., J. Biol. Chem., 1996, 271, 2608, (pharmacol)
• Caporale, G. et al., Experientia, 1967, 23, 985, (pharmacol)
• Bender, D.R. et al., J.O.C., 1979, 44, 2176, (synth)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1098
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 684C, (ir)
• Dimitrova, D. et al., Nucleic Acids Res., 1993, 21, 5554, (pharmacol)
• Scheel, L.D. et al., Biochemistry, 1963, 2, 1127, (isol)
• Taskineu, J. et al., Biomed. Mass Spectrom., 1980, 7, 556, (ms)
• Russev, G. et al., J. Mol. Biol., 1982, 161, 77, (pharmacol)
• Nivsarkar, M. et al., Biochem. Mol. Biol. Int., 1996, 38, 625, (pharmacol)
• Kaufman, K.D., J.O.C., 1961, 26, 117; 1980, 45, 738, (synth, uv)
• IARC Monog., 1986, 40, 357; Suppl. 7, 366; Suppl. 6, 541, (rev, tox)