物质信息
ID:449756
名称和标识
IUPAC标准名
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
别名
GantanolSulfamethoxazole
IUPAC传统名
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Sulfonamide bacteriostatic antibiotic
Used in treatment of respiratory and urinary tract infections
药理学性质
生物活性机理
Restrict folate synthesis through competitive antagonism of PABA
Folate synthesis inhibitor
Folate antagonist
描述信息
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分子图谱
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参考文献
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 208
• Bushby, S.R.M. et al., Handb. Exp. Pharmacol., 1983, 64, 75; 163; 185, (revs)
• U.K. Pat., 1959, 814276; CA, 55, 20091c, (synth)
• Manzo, R.H. et al., J. Pharm. Sci., 1973, 62, 152, (uv)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1514; 3212
• Fujimoto, M. et al., Chem. Pharm. Bull., 1962, 10, 572-575, (derivs)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, SNK000
• Iwai, I. et al., Chem. Pharm. Bull., 1966, 14, 1277, (synth)
• Brumfitt, W. et al., J. Infect. Dis., 1973, 128, 5778, (rev, pharmacol)
• Rudy, B.C. et al., Anal. Profiles Drug Subst., 1973, 2, 467, (rev, synth, props)
• Maury, L. et al., Can. J. Chem., 1985, 63, 3012, (cryst struct, ir, Raman)
• IARC Monog., 1980, 24, 285; Suppl. 7, 348; Suppl. 6, 502, (rev, tox)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)