物质信息
ID:449746
名称和标识
别名
ViramuneNevirapine
IUPAC标准名
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
IUPAC传统名
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Virucide
Used to treat HIV-1 infection and AIDS
药理学性质
生物活性机理
Non-nucleoside reverse transcriptase inhibitor (NNRTI)
描述信息
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分子图谱
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参考文献
• Koup, R.A. et al., J. Infect. Dis., 1991, 163, 966, (pharmacol)
• Grob, P.M. et al., AIDS Res. Hum. Retroviruses, 1992, 8, 145, (pharmacol, rev)
• Pedersen, O.S. et al., Synthesis, 2000, 479-495, (rev)
• Hargrave, K.D. et al., J. Med. Chem., 1991, 34, 2231, (synth, pharmacol)
• Skoog, M.T. et al., Med. Res. Rev., 1992, 12, 27, (rev)
• Eur. Pat., 1991, Boehringer Ingelheim, 429 987; CA, 115, 114559n, (synth, pharmacol)
• Merluzzi, V.J. et al., Adv. Exp. Med. Biol., 1992, 312, 89, (rev)
• Mui, P.W. et al., J. Med. Chem., 1992, 35, 201, (cryst struct)
• Grozinger, K.G. et al., J. Het. Chem., 1995, 32, 259, (synth)
• Cohen, K.A. et al., J. Biol. Chem., 1991, 266, 14670, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1393
• Merluzzi, V.J. et al., Science (Washington, D.C.), 1990, 250, 1411, (pharmacol)