物质信息
ID:449744
名称和标识
IUPAC标准名
methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
IUPAC传统名
methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
别名
FluoxetineProzac
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT(1A) autoreceptors.
Selective serotonin-reuptake inhibitor (SSRI).
产品相关信息
应用领域
Antidepressant
Used for the treatment of premenstrual dysphoric disorder.
Psychostimulant
描述信息
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分子图谱
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参考文献
• Lenberger, L. et al., J. Clin. Psychiatry, 1985, 46, 14, (pharmacol, metab)
• Benfield, P. et al., Drugs, 1986, 32, 481, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 284
• Miles, W.H. et al., Tetrahedron, 2001, 57, 9925-9929, (synth)
• Lautz, R.J. et al., J. Chromatogr., 1993, 614, 175, (gc)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 5753
• Cheer, S.M. et al., Drugs, 2001, 61, 81-110, (rev)
• Gao, Y. et al., J.O.C., 1988, 53, 4081, (R-form, synth, abs config, ir, pmr)
• Corey, E.J. et al., Tet. Lett., 1989, 30, 5207, (R-form, synth)
• Ch^enevert, R. et al., Tetrahedron, 1992, 48, 6769, (R-form, S-form)
• Gram, L., N. Engl. J. Med., 1994, 331, 1354, (pharmacol, rev)
• Sakuraba, S. et al., Chem. Pharm. Bull., 1995, 43, 748, (synth)
• Mitchell, D. et al., Synth. Commun., 1995, 25, 1231, (synth)
• Hilborn, J.W. et al., Tet. Lett., 2001, 42, 8919-8921, (synth)
• Hisrich, K.R. et al., J. Pharm. Technol., 1987, 3, 219, (rev)
• Wong, D.T. et al., Life Sci., 1995, 57, 411, (pharmacol, rev)
• Robertson, D.W. et al., J. Med. Chem., 1988, 31, 1412, (synth, abs config, resoln, pharmacol)
• Altamura, A.C. et al., Clin. Pharmacokinet., 1994, 26, 201, (rev, pharmacokinet)
• Risley, D.S. et al., Anal. Profiles Drug Subst., 1990, 19, 193, (rev)
• U.S. Pat., 1977, 4 018 895; CA, 87, 134520z, (synth, pharmacol)
• Feighner, J.P. et al., Selective Serotonin Re-uptake Inhibitors, J. Wiley, 1991, (book)