物质信息
ID:449736
名称和标识
IUPAC标准名
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
别名
AminoglutethimideCytadrenEliptenOrimeten
IUPAC传统名
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Cholesterol desmolase inhibitor
Aromatase inhibitor
Corticosteroid antagonist
Inhibits hydroxylations required for aromatization of androgens to estrogens
Androgen synthesis inhibitor
Mineralocorticoid synthesis inhibitor
Corticosteroid synthesis inhibitor
产品相关信息
应用领域
Originally used as anticonvulsant, withdrawn due to adrenotoxicity.
Inhibits adrenal corticosteroid synthesis
Now used as aromatase inhibitor for treatment of breast cancer in postmenopausal women and for treatment of secondary hyperaldosteronism and oedema
描述信息
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参考文献
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AKC600
• Santen, R.J. et al., Pharmanual (Basel), Vol. 2: A Comprehensive Guide to the Therapeutic Use of Aminoglutethimide, Karger, Basel, Switz., 1981, (book)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 454
• Aboul-Enein, H.Y. et al., J. Med. Chem., 1975, 18, 736, (synth, pharmacol)
• Aboul-Enein, H.Y., Anal. Profiles Drug Subst., 1986, 15, 35, (rev)
• Lee, C.M. et al., J.A.C.S., 1961, 83, 4586, (uv, ir)
• Chang, M.-Y. et al., Tet. Lett., 2000, 41, 10273-10276, (synth)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1969, 302, 204, (ms)
• Defay, N. et al., J. Pharm. Belg., 1972, 27, 335, (pmr)
• Van Roey, P. et al., Acta Cryst. C, 1991, 47, 829, (cryst struct, bibl)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 404A, (ir)
• Salhanick, H.A., Cancer Res., 1982, 42, 3315, (pharmacol)
• Bushell, S.M. et al., Tetrahedron, 1998, 54, 2269-2274, (synth, ir, pmr, cmr)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1456C, (nmr)