物质信息
ID:449735
名称和标识
IUPAC标准名
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
IUPAC传统名
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
别名
FluphenazineFlufenazine
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Dopamine-release inhibitor
Postsynaptic dopamine-antagonist in: basal ganglia; hypothalamus; limbic-system; brain-stem; medulla
Dopamine-antagonist
Dopamine-turnover stimulant in the forebrain
Increases neuronal firing-rate in the midbrain
Mechanism of action not fully understood.
Calmodulin-antagonist
产品相关信息
应用领域
Tranquilliser
Neuroleptic
Psychosedative
描述信息
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分子图谱
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参考文献
• Ger. Pat., 1964, 1 165 602; CA, 60, 15886, (deriv)
• Kreyenbuehl, B. et al., Pharm. Acta Helv., 1979, 54, 197, (uv, ir)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6546; 7787; 7963, (synonyms)
• U.K. Pat., 1960, 829 246; CA, 54, 17428
• Gowda, H.S. et al., Rev. Roum. Chim., 1977, 22, 745; CA, 87, 126635a, (use)
• Curry, S.H. et al., Br. J. Clin. Pharmacol., 1979, 7, 325, (metab)
• Shetty, H.U. et al., Biomed. Mass Spectrom., 1983, 10, 601, (ms)
• U.S. Pat., 1965, 3 194 733; CA, 64, 5114, (derivs)
• Clarke, G., Anal. Profiles Drug Subst., 1980, 9, 275, (rev, decanoate)
• Phenothiazines and 1,4-Benzothiazines, (ed. Gupta, R.R.), Elsevier, Amsterdam, 1988, (book, pharmacol)
• U.K. Pat., 1960, 833 473; CA, 54, 21143
• Yale, H.L. et al., J.A.C.S., 1960, 82, 2039, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 596
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FMP000; PMI250; TJW500