物质信息
ID:449734
名称和标识
IUPAC标准名
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
别名
SparfloxacinZagamSpara
IUPAC传统名
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Leprostatic and antitubercular agent
Broad spectrum antibacterial agent
药理学性质
生物活性机理
Quinolones can enter cells easily and therefore are often used to treat intracellular pathogens such as Legionella pneumophila and Mycoplasma pneumoniae.
Eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
For many gram-negative bacteria DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria.
Inhibitor of bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription.
描述信息
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参考文献
• Lewin, C.S. et al., J. Antimicrob. Chemother., 1992, 30, 625, (activity)
• Shimada, J. et al., Clin. Pharmacokinet., 1993, 25, 358, (pharmacokinet, rev)
• Chaudhry, A.Z. et al., Antimicrob. Agents Chemother., 1990, 34, 1843; 2442, (activity)
• Kagemoto, A. et al., Arzneim.-Forsch., 1991, 41, 744, (synth)
• Matsunaga, Y. et al., Arzneim.-Forsch., 1991, 41, 747; 760, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 202
• Miyamoto, T. et al., J. Med. Chem., 1990, 33, 1645, (cryst struct, synth, pharmacol)
• Qadri, S.M. et al., Chemotherapy (Basel), 1992, 38, 99, (activity)
• Richard, P. et al., J. Antimicrob. Chemother., 1992, 30, 739, (rev)
• Nakamura, S. et al., Antimicrob. Agents Chemother., 1989, 33, 1167; 1990, 34, 89, (pharmacol, activity)
• Borner, K. et al., J. Chromatogr., 1992, 579, 285, (hplc)
• Goa, K.L. et al., Drugs, 1997, 54, 700-725, (rev)
• Drugs of the Future, 1989, 14, 413, (rev)
• Nogita, T. et al., J. Antimicrob. Chemother., 1991, 28, 313, (pharmacokinet)