物质信息
ID:449724
名称和标识
IUPAC标准名
4-amino-N-(6-methoxypyridazin-3-yl)benzene-1-sulfonamide
别名
SulfamethoxypyridazineSulphamethoxypyridazineKynexMidicelSulfalexLederkynExazol
IUPAC传统名
4-amino-N-(6-methoxypyridazin-3-yl)benzene-1-sulfonamide
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Dihydrofolate reductase inhibitor
Folate antagonist
产品相关信息
应用领域
Long-acting sulfonamide used for treatment of systemic infections.
Antiseptic
Low acute toxicity
描述信息
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分子图谱
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参考文献
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1932; 2752
• Kracmar, J. et al., Pharmazie, 1975, 30, 447, (uv)
• Bhni, E. et al., Chemotherapia, 1969, 14, 195, (pharmacol)
• Edwards, D., J. Pharm. Pharmacol., 1971, 23, 956, (ir)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 210
• U.S. Pat., 1958, 2 833 761; CA, 52, 20216, (deriv)
• Turzcan, J. et al., J. Pharm. Sci., 1972, 61, 434, (pmr)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AKO500
• Horie, T. et al., Chem. Pharm. Bull., 1962, 10, 580, (synth)
• Grechishkin, V.S. et al., J. Mol. Struct., 1982, 83, 345, (nqr, nmr)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr)
• Basak, A.K. et al., Acta Cryst. C, 1987, 43, 735, (cryst struct)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876, (rev)