物质信息
ID:449716
名称和标识
IUPAC标准名
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
别名
IsoptinIproveratrilBerkatensCordiloxEthimilUniverVasolanVerapressVerapamilCoveraGeanginVerelanSecuronCalan
IUPAC传统名
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Calcium antagonist
Inhibits movement of calcium ions across the cell membrane
Protein kinase C inhibitor
产品相关信息
应用领域
Coronary vasodilator
Smooth muscle relaxant.
Used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches.
Antiarrhythmic (class IV) agent
描述信息
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分子图谱
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参考文献
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• Hofer, C.A. et al., Am. J. Med., 1993, 95, 431, (tox)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, IRV000; VHA450
• Larangh, J.H., Am. J. Cardiol., Ed., Part 7, 1986, 57, (book)
• Echizen, H. et al., Clin. Pharmacokinet., 1986, 11, 425, (rev)
• Dooley, M. et al., Drugs, 1998, 56, 837-844, (rev)
• Baky, S.H. et al., Pharmacol. Biochem. Prop. Drug Subst., 1981, 3, 226, (rev, pharmacol)
• Scheid, W. et al., Arzneim.-Forsch., 1991, 41, 901, (tox)
• Longstreth, J.A., Drug Stereochem., (Ed. Wainer, I.W.), M. Dekker, 1993, 315, (rev)
• Bannister, R.M. et al., Org. Process Res. Dev., 2000, 4, 467-472, (synth, pmr)
• Theodore, L.J. et al., J.O.C., 1987, 52, 1309, (synth)
• Knoll, A.G., Angew. Chem., Int. Ed., 1964, 3, 68, (synth, pharmacol)
• Ger. Pat., 1978, 2 631 222; CA, 88, 169796, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10669; 10670
• Brogden, R.N. et al., Drugs, 1996, 51, 792, (rev)
• Brenna, E. et al., Eur. J. Org. Chem., 2001, 1349-1357, (synth)
• Ramuz, H., Helv. Chim. Acta, 1975, 58, 2050, (synth, ir, ms, pmr, abs config)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 960