物质信息
ID:449706
名称和标识
IUPAC标准名
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
别名
4',4''-Difluorocinnarizine1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazineFlunarizine
IUPAC传统名
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity
Calcium channel blocker
产品相关信息
应用领域
Effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
描述信息
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参考文献
• Marini, D. et al., Boll. Chim. Farm., 1984, 123, 133, (struct, uv, ir)
• Ger. Pat., 1972, 2 220 242; CA, 78, 29815r, (synth)
• Amery, W.K. et al., Drugs Exp. Clin. Res., 1981, 7, 1, (pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7382, (synonyms)
• Xiang, M. et al., CA, 1985, 102, 78835, (synth)
• Schmidt, R. et al., J. Cardiovasc. Pharmacol., (Suppl. 8), 1991, 18, S27, (rev)
• Holmes, B. et al., Drugs, 1984, 29, 6, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 939
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FDD080