物质信息
ID:449674
名称和标识
IUPAC标准名
5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
别名
FtorafurTegafurCitofurSinoflurolFurflucilNeberkFutraful
IUPAC传统名
5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antineoplastic agent
Cytostatic
药理学性质
生物活性机理
Thymidylate synthetase inhibitor
RNA synthesis inhibitor
Fluorouracil prodrug
DNA synthesis inhibitor
描述信息
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分子图谱
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参考文献
• Fujimoto, S., Drugs of Today (Barcelona), 1985, 21, 125, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 878
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 502
• Loo, T.L. et al., Drug Metab. Rev., 1978, 8, 137, (metab, rev)
• Au, J. et al., Cancer Chemother. Pharmacol., 1981, 7, 55, (metab)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 366A, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 811D, (ir)
• Yamamoto, S. et al., Arzneim.-Forsch., 1981, 31, 1268, (pharmacol)
• Ozaki, S. et al., Chem. Pharm. Bull., 1986, 34, 150, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FMB000; UNJ810
• Yasumoto, M. et al., J. Med. Chem., 1977, 20, 1592, (synth, resoln)
• Uchida, T. et al., Chem. Pharm. Bull., 1993, 41, 1632, (polymorphism)
• Nakai, Y. et al., Chem. Pharm. Bull., 1982, 30, 2629; 1986, 34, 1242, (cryst struct, bibl)