物质信息
ID:449655
名称和标识
IUPAC标准名
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
IUPAC传统名
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
别名
2',3'-Dideoxy-1,9-dihydro-9-beta- D -ribofuranosyl-6 H -purin-6-one; 2',3'-DideoxyinosineVidexDidanosine
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Potentially of use against HIV infection and used in combination with other antiretroviral drug therapy as part of highly active
Nucleoside transporter substrate.
Antiviral agent
药理学性质
生物活性机理
Reverse Transcriptase inhibitor
Cell proliferation inhibitor
描述信息
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分子图谱
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参考文献
• Ray, G. et al., Anal. Lett., 1987, 20, 1815, (hplc)
• Chu, C.K. et al., J.O.C., 1989, 54, 2217, (synth, pmr)
• McGowan, J.J. et al., Rev. Infect. Dis., 1990, 12, S513, (rev, antiretroviral props)
• Nassar, M.N. et al., Anal. Profiles Drug Subst., 1993, 22, 185, (rev)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 215B, (nmr)
• Wu, X. et al., J. Biol. Chem., 1992, 267, 8813-8818, (pharmacol)
• Bhat, V. et al., Synth. Commun., 1992, 22, 1481, (synth, pmr, uv)
• Mitsuya, H. et al., Proc. Natl. Acad. Sci. U.S.A., 1986, 83, 1911, (pharmacol)
• Shelton, M.J. et al., Ann. Pharmacother., 1992, 26, 660, (rev)
• Hao, Z. et al., Mol. Pharmacol., 1988, 34, 431, (pharmacol)
• Ahluwalia, G. et al., Biochem. Pharmacol., 1987, 36, 3797