物质信息
ID:449650
名称和标识
IUPAC标准名
(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
别名
TestosteroneAtmosAndropatch
IUPAC传统名
(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
数据登录号
CAS号
化合物性质
产品相关信息
生物来源
Constit. of human urine
应用领域
Used in the treatment of male hypogonadism (transdermal administration)
药理学性质
生物活性机理
High dose: spermatogenesis inhibitor
FSH antagonist.
The steroid receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action
Exogenous administration inhibits endogenous release via feedback inhibition of pituitary ICSH
Activity in many tissues appears to depend on reduction to dihydrotestosterone which binds to cytosolic receptor proteins
Androgen
ICSH antagonist
Gonadotropin antagonist
描述信息
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参考文献
• Lampe, V., Ber., 1918, 51, 1347, (synth)
• Kuroyagi, M. et al., Yakugaku Zasshi, 1970, 90, 1467; CA, 74, 61612a, (isol)
• Holder, G.M. et al., Xenobiotica, 1978, 8, 761, (metab)
• Quint, P. et al., Fresenius' Z. Anal. Chem., 1977, 285, 356; 1979, 295, 269, (detn, B)
• Tonnesen, H.H. et al., Acta Chem. Scand., Ser. B, 1982, 36, 475, (cryst struct, bibl)
• Encyclopedia of Food and Color Additives, (ed. Burdock, G.A.), CRC Press, 1997, 2856-2858
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 800B, (nmr)
• Srinivasan, K.R., J. Pharm. Pharmacol., 1953, 5, 448, (derivs)
• Jentzsch, K. et al., Sci. Pharm., 1968, 36, 251; CA, 70, 90793h, (isol)
• Roughley, P.J. et al., J.C.S. Perkin 1, 1973, 2379-2388, (biosynth)
• Karig, F., Dtsch. Apoth. -Ztg., 1975, 115, 325; CA, 83, 65372f, (derivs)
• Sastry, B.S., Res. Ind., 1970, 15, 258; CA, 75, 75063e, (isol)
• Jitoe, A. et al., J. Agric. Food Chem., 1992, 40, 1337-1340, (occur)
• Khar, A. et al., FEBS Lett., 1999, 445, 165-168, (antitumour props)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 52C, (ir)
• Dyrssen, D.W. et al., Anal. Chim. Acta, 1972, 60, 139, (detn, B)
• Kashina, C. et al., Heterocycles, 1977, 7, 241, (synth)
• Ammon, H.P.T. et al., Planta Med., 1991, 57, 1-7, (rev, pharmacol)
• Wahlstrom, B. et al., Acta Pharmacol. Toxicol., 1978, 43, 86, (metab)
• Cheng, K.L. et al., Handbook of Organic Analytical Reagents, CRC Press, Boca Raton, 1982, 511, (use)