物质信息
ID:449649
名称和标识
IUPAC标准名
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
别名
CurcuminDiferuloylmethaneCurcuma yellow
IUPAC传统名
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Inhibitor of eicosanoid biosynthesis
Acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage
Induce glutathione S-transferase and are potent inhibitors of cytochrome P450;
产品相关信息
应用领域
Antitumor
Antiamyloid
Antiarthritic
Bile stimulant showing hepatoprotective props
Antiinflammatory agent
Possesses bactericidal and fungicidal props.
生物来源
Isol. from Curcuma zedoaria (turmeric), other Curcuma spp. and other spp.
简要说明
Tautomers
描述信息
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分子图谱
暂无数据
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参考文献
• Umland, F. et al., Fresenius' Z. Anal. Chem., 1963, 197, 151, (detn, Ni)
• Jitoe, A. et al., J. Agric. Food Chem., 1992, 40, 1337-1340, (occur)
• Jentzsch, K. et al., Sci. Pharm., 1968, 36, 251; CA, 70, 90793h, (isol)
• Sastry, B.S., Res. Ind., 1970, 15, 258; CA, 75, 75063e, (isol)
• Kuroyagi, M. et al., Yakugaku Zasshi, 1970, 90, 1467; CA, 74, 61612a, (isol)
• Dyrssen, D.W. et al., Anal. Chim. Acta, 1972, 60, 139, (detn, B)
• Karig, F., Dtsch. Apoth. -Ztg., 1975, 115, 325; CA, 83, 65372f, (derivs)
• Ammon, H.P.T. et al., Planta Med., 1991, 57, 1-7, (rev, pharmacol)
• Quint, P. et al., Fresenius' Z. Anal. Chem., 1977, 285, 356; 1979, 295, 269, (detn, B)
• Kashina, C. et al., Heterocycles, 1977, 7, 241, (synth)
• Holder, G.M. et al., Xenobiotica, 1978, 8, 761, (metab)
• Cheng, K.L. et al., Handbook of Organic Analytical Reagents, CRC Press, Boca Raton, 1982, 511, (use)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 800B, (nmr)
• Lampe, V., Ber., 1918, 51, 1347, (synth)
• Spicer, G.S. et al., Anal. Chim. Acta, 1958, 18, 231, (detn, B)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 52C, (ir)
• Srinivasan, K.R., J. Pharm. Pharmacol., 1953, 5, 448, (derivs)
• Roughley, P.J. et al., J.C.S. Perkin 1, 1973, 2379-2388, (biosynth)
• Wahlstrom, B. et al., Acta Pharmacol. Toxicol., 1978, 43, 86, (metab)
• Tonnesen, H.H. et al., Acta Chem. Scand., Ser. B, 1982, 36, 475, (cryst struct, bibl)