物质信息
ID:449647
名称和标识
IUPAC标准名
2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
别名
Magnolol
IUPAC传统名
2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiplatelet agent
Sedative
Antibacterial, antifungal agent
Relaxant
Shows antiinflammatory and analgesic effects
生物来源
Constit. of Sassafras randaiense and Magnolia spp.
药理学性质
生物活性机理
Reported from in-vitro study in rat aorta to produce relaxation of vascular smooth-muscle mediated by: release of endothelium derived relaxant factor
CNS depressant with serotonergic activity
Inhibition of calcium influx through voltage gated channels
描述信息
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分子图谱
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参考文献
• El-Feraly, F.S. et al., J. Nat. Prod., 1983, 46, 493
• Tsai, T.-H. et al., Drug Metab. Dispos., 1994, 22, 518, (hplc, pharmacokinet)
• Agharahimi, M.R. et al., J.O.C., 1995, 60, 1856, (synth, ir, pmr, cmr, ms)
• Wang, Y. et al., J. Chin. Chem. Soc. (Peking), 1982, 30, 215, (cryst struct)
• Clark, A.M. et al., J. Pharm. Sci., 1981, 70, 951, (props)
• Hattori, M. et al., Chem. Pharm. Bull., 1984, 32, 5010; 1986, 34, 158, (metab)
• Wang, J.-P. et al., Naunyn-Schmiedeberg's Arch. Pharmacol., 1992, 346, 707, (pharmacol)
• Ho, T.I. et al., CA, 1986, 105, 152803, (synth)
• Watanabe, K. et al., Planta Med., 1983, 49, 103, (isol, pharmacol)
• Runeberg, J. et al., Acta Chem. Scand., 1957, 11, 1060; 1958, 12, 188
• Kim, Y.-K. et al., Planta Med., 1996, 65, 291-292, (activity)
• Teng, C.-M. et al., Thromb. Res., 1988, 50, 757, (pharmacol)
• Tsai, T.-H. et al., Neurosci. Lett., 1995, 186, 49, (pharmacol)