物质信息
ID:449638
名称和标识
别名
1-DehydrocortisolPrednisoloneHydeltraDelta-Cortef
IUPAC标准名
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
IUPAC传统名
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antineoplastic agent
Adrenergic agent
Antiinflammatory agent
药理学性质
生物活性机理
Glucocorticoid receptor agonist.
On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes.
The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
描述信息
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参考文献
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Zicha, L. et al., Arzneim.-Forsch., 1960, 10, 728; 831, (pharmacol, derivs)
• Gonzalez, M.D. et al., Org. Magn. Reson., 1984, 22, 586, (cmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6297; 6321; 6941
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 737
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 585B, (nmr)
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Hirschmann, R. et al., J.A.C.S., 1964, 86, 3903, (synth)
• Ali, S.L., Anal. Profiles Drug Subst., 1992, 21, 415, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AAF625; PMA000; PMA100; SOV100; PLY300
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)
• Gambertoglis, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev, pharmacol)
• Jusko, W.J. et al., Ther. Drug Monit., 1980, 2, 169, (rev, pharmacol)
• Toft, P. et al., Can. J. Spectrosc., 1970, 15, 137, (ms)
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (biosynth)