物质信息
ID:449621
名称和标识
别名
Kendall's compound FHydrocortisoneReichstein's Substance M;CortefHydrocortoneEfcortelan;FicortrilHydrocortalHytoneCortenemaCortisol;11beta,17alpha,21-Trihydroxyprogesterone
IUPAC标准名
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
IUPAC传统名
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Phosphorus mobilizer
Gluconeogenesis promoter
Glycogen deposition inhibitor
ACTH secretion inhibitor
Calcium mobilizer
Glucocorticoid
产品相关信息
应用领域
Topical antiinflammatory agent
Antiallergic
Immunosuppressive
生物来源
Adrenal cortical hormone
描述信息
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分子图谱
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参考文献
• van der Sijde, D. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 721, (synth)
• Zaffaroni, A. et al., J.A.C.S., 1951, 73, 1390, (biosynth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 584C, (nmr)
• v. Euw, J. et al., Helv. Chim. Acta, 1942, 25, 988, (struct)
• Reichstein, T., Helv. Chim. Acta, 1937, 20, 953, (isol)
• Shirasaka, M., Chem. Pharm. Bull., 1961, 9, 152, (synth)
• Saucy, G. et al., Helv. Chim. Acta, 1966, 49, 1529; 1967, 50, 1394, (synth, ir, uv, pmr)
• Haskins, N.J. et al., Biomed. Mass Spectrom., 1974, 1, 423, (ms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BAV275; HHR000; CNS750; HHQ800; HHQ825; HHQ850; HHQ875
• Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (use)
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6346; 6986; 7335
• Genard, P., Org. Mass Spectrom., 1979, 12, 396, (pmr)
• Castellano, E.E. et al., Acta Cryst. B, 1980, 36, 3063, (cryst. struct)
• Minagawa, K. et al., J.C.S. Perkin 1, 1988, 587, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 734
• Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731, (synth, struct, pmr)
• Bhacca, N.S. et al., J.A.C.S., 1973, 95, 8421, (cmr)
• Florey, K., Anal. Profiles Drug Subst., 1983, 12, 277, (rev, synth, pharmacol, anal)