物质信息
ID:449611
名称和标识
IUPAC标准名
(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
别名
Penicillanic acid sulfoneSulbactam3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxideAntibiotic CP 45899
IUPAC传统名
(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Inhibits beta-lactamases of the Richmond-Sykes types I; II; III; IV; V
Beta-Lactamase inhibitor
产品相关信息
应用领域
Has only weak antibacterial activity except against Neisseria gonorrhoeae; Neisseria meningitidis
Antibiotic
描述信息
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分子图谱
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参考文献
• Ger. Pat., 1978, 2 854 535; CA, 90, 121589r, (synth, pharmacol)
• Kapur, J.C. et al., Tet. Lett., 1985, 26, 3875, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 250
• Sheehan, J.C. et al., J.A.C.S., 1953, 75, 3292; 1959, 81, 5838
• Noguchi, J.K. et al., Clin. Pharm., 1988, 7, 37, (rev)
• Barrett, A.G.M. et al., J.O.C., 1990, 55, 5110, (synth, ir, pmr, ms)
• Howard, A.J. et al., Drugs Exp. Clin. Res., 1979, 5, 7, (pharmacol)
• Foulds, G. et al., Antimicrob. Agents Chemother., 1983, 23, 692, (props)
• Gibon, V. et al., Acta Cryst. C, 1988, 44, 652, (cryst struct)
• Volkmann, R.A. et al., J.O.C., 1982, 47, 3344, (synth)
• Brenner, D.G. et al., Biochemistry, 1981, 20, 3680; 1984, 23, 5833, (synth, props)
• Evrard, E. et al., Nature (London), 1964, 201, 1124, (gc, esters)
• Yang, X. et al., CA, 1986, 104, 224752, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PAP600