物质信息
ID:449603
名称和标识
别名
FenospenOspenVebecillinApopenFenoxypenStabicillinOratrenPhenocillinPen-VeePhenoxymethylpenicillinFenacillinFenocinMeropeninOracillin
IUPAC传统名
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
IUPAC标准名
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Binds penicillin binding protein 3
Cell-wall mucopeptide synthesis inhibitor
Binds penicillin binding protein 1Bs
产品相关信息
应用领域
Orally absorbed antibiotic active against gram-positive bacteria
描述信息
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分子图谱
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参考文献
• Voldeng, A.N. et al., J. Het. Chem., 1979, 16, 621, (synth)
• Brandl, E. et al., Wien. Med. Wochenschr., 1953, 602, (manuf)
• Sheehan, J. et al., J.A.C.S., 1957, 79, 1262; 1959, 81, 3089; 1962, 84, 2983, (synth)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 3, 129
• Shin, W. et al., Acta Cryst. C, 1992, 48, 1447, (cryst struct, ester)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PDT500; PDT750
• Bose, A. et al., J.A.C.S., 1968, 70, 4506, (epimer)
• Chang, C.-J. et al., J. Pharm. Sci., 1979, 68, 64, (cmr)
• Sieh, D.H., Anal. Profiles Drug Subst., 1988, 17, 677, (rev)
• Glombitza, K., Annalen, 1964, 673, 166, (synth)
• Jensen, E.B. et al., Eur. J. Appl. Microbiol. Biotechnol., 1981, 13, 29, (manuf)
• Josefsson, K. et al., Chemotherapy (Basel), 1982, 28, 241, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 191
• Nicolaou, K.C. et al., Classics in Total Synthesis, Targets, Strategies, Methods, VCH, 1996, 41, (bibl, synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3992; 7789, (synonyms)