物质信息
ID:449555
名称和标识
IUPAC标准名
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
别名
CaffeineMethyltheobromineCafipelTheineGuaranineCoffeine
IUPAC传统名
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Psychotonic
In the horse is used to treat colic, heat stroke, circulatory disturbance and fatigue, also for horse doping
Psychostimulant
Flavouring ingredient
Diuretic
Widely used CNS, respiratory and cardiac stimulant, main effect on the cerebral cortex
Possesses virucidal props
Used in many beverages
Analeptic
Chemosterilant against stored grain pests.
生物来源
Component of coffee beans ( Coffea arabica ), many other Coffea spp., chocolate ( Theobroma cacao ), tea ( Camellia thea ), kolanut ( Cola acuminata ) and several other Cola spp.
and several other plants (Rubiaceae, Sterculiaceae, Theaceae).
Also occurs as a fungal metab. of Claviceps sorghicola
药理学性质
生物活性机理
Inhibitor of cyclic nucleotide phosphodiesterases
Modulator of intracellular calcium handling
Antagonist of adenosine receptors
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Sutor, D.J., Acta Cryst., 1958, 11, 453, (cryst struct)
• Aldrich Library of NMR Spectra, 2nd edn., 1983, 2, 586A, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 710B, (ir)
• Blout, E.R. et al., J.A.C.S., 1950, 72, 479, (ir)
• Zubair, M.U. et al., Anal. Profiles Drug Subst., 1986, 15, 71, (rev, ir, uv, pmr, cmr, ms, occur, anal)
• Bogo, A. et al., Phytochemistry, 2000, 54, 937-939, (isol, ms)
• Fischer, E. et al., Ber., 1895, 28, 2473; 3135, (synth)
• Twanmoh, L.-M. et al., J. Het. Chem., 1973, 10, 187, (pmr)
• Nicolau, C. et al., Z. Naturforsch., C, 1974, 29, 475, (cmr)
• Lewis, R.J., Food Additives Handbook, Van Nostrand Reinhold International, New York, 1989, CAK500
• Sitkowski, J. et al., Spectrochim. Acta A, 1995, 51, 839, (pmr, cmr, N-15 nmr)
• Parliment, T.H. et al., ACS Symp. Ser., 2000, 754
• Bredereck, H. et al., Chem. Ber., 1950, 83, 201; 1962, 95, 1902, (synth)
• IARC Monog., 1991, 51, 291, (rev, tox)
• Spiteller, G. et al., Monatsh. Chem., 1962, 93, 632, (ms)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 921
• Somani, S.M. et al., Int. J. Clin. Pharmacol., Ther. Toxicol., 1988, 26, 521, (rev)
• Encyclopedia of Food and Color Additives, (ed. Burdock, G.A.), CRC Press, 1997, 363
• Caffeine, (ed. Spiller, G.A.), CRC Press, 1998, (book)
• Suzuki, T. et al., Phytochemistry, 1976, 15, 1235, (biosynth)
• Arnaud, M.J., Prog. Drug Res., 1987, 31, 273, (rev, chem, pharmacol, toxicity)
• Benowitz, N.L. et al., Annu. Rev. Med., 1990, 41, 277, (rev, pharmacol)
• Bott, K., Chem. Ber., 1993, 126, 1955, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CAK500