物质信息
ID:449392
名称和标识
IUPAC标准名
(10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one
别名
CondyloxCondylineWarticonPodofilox
IUPAC传统名
(10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Reported to bind to tubulin
Inhibitor of human DNA topoisomerase II
Cell division inhibitor
产品相关信息
生物来源
Isol. from Podophyllum emodi, Diphylleia grayi and others
应用领域
Cytostatic
描述信息
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分子图谱
暂无数据
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参考文献
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• Macdonald, D.I. et al., J.O.C., 1986, 51, 4749, (synth)
• Hartwell, J.L. et al., J.A.C.S., 1951, 73, 2909, (isol)
• Kamil, W.M. et al., Phytochemistry, 1986, 25, 2093, (biosynth)
• Jones, D.W. et al., Chem. Comm., 1987, 1797; 1989, 1370, (synth)
• Forsey, S.P. et al., J.O.C., 1989, 54, 4280, (synth)
• Wichers, H.J. et al., Phytochemistry, 1991, 30, 3601, (biosynth)
• Pelter, A. et al., Tetrahedron, 1994, 50, 10829, (synth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1304A, (nmr)
• Stoll, A. et al., J.A.C.S., 1954, 76, 3103, (glucoside)
• Inamori, Y. et al., Chem. Pharm. Bull., 1986, 34, 3928, (props)
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• Andersen, K.V. et al., J.C.S. Perkin 2, 1990, 1871, (cryst struct)
• Ayres, D.C. et al., Lignans, Chem. Biol. and Clinical Props., Cambridge, 1990, (rev)
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• Andrews, R.C. et al., J.A.C.S., 1988, 110, 7854, (synth)
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• Ward, R.S., Synthesis, 1992, 719, (rev, synth, bibl)
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• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 765
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 320A, (ir)
• Vyas, D.M. et al., Tet. Lett., 1986, 27, 3099, (synth)
• Van Speybroeck, R. et al., Tetrahedron, 1991, 47, 4675, (synth)
• Schrecker, A.W. et al., J.O.C., 1956, 21, 288; 381, (props, abs config)
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• Ayres, D.C. et al., J.C.S. Perkin 1, 1972, 1343, (pmr)
• Petcher, T.J. et al., J.C.S. Perkin 2, 1973, 288, (cryst struct)
• Van der Eycken, J. et al., Tetrahedron, 1986, 42, 4297, (synth)
• Lim, Y.-H. et al., Arch. Pharmacal Res., 1999, 22, 208-212, (Angeloylpodophyllotoxin)
• Canel, C. et al., Phytochemistry, 2000, 54, 115-120, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, EBB600
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