物质信息
ID:449342
名称和标识
IUPAC标准名
1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione
别名
EmodinEmodolArchinAlatinoneRheum-emodinFrangulinic acidFrangula emodin
IUPAC传统名
1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antimicrobial
Antineoplastic agent
Cathartic agent
生物来源
Present in Cascara sagrada, in aloes and in other plant material.
Isol. from Penicillium spp., Aspergillus spp. and from Anixiella micropetrusa
药理学性质
生物活性机理
Monoamine oxidase inhibitor
Inhibitor of phosphoinositide- 3-kinase (PI3K)/AKT
描述信息
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分子图谱
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参考文献
• Banville, J. et al., J.C.S. Perkin 1, 1976, 1852
• Kalidhar, S.B., Phytochemistry, 1989, 28, 2455; 3459, (pmr)
• Steglich, W. et al., Chem. Ber., 1972, 105, 2928
• Wagner, H., Tet. Lett., 1972, 5013
• Macias, M. et al., J. Nat. Prod., 2000, 63, 757-761, (Emodin, activity)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 88D, (ir)
• Hrhammer, H.P. et al., Z. Naturforsch., B, 1972, 27, 959
• Okabe, H., Chem. Pharm. Bull., 1973, 21, 1254
• Fairbairn, J.W., Pharmacology, Suppl. 1, 1976, 14, 1, (rev)
• Fujimoto, H. et al., Chem. Pharm. Bull., 1998, 46, 1506-1510, (isol, activity)
• Schmidt, R.R. et al., Synthesis, 1994, 255, (synth, pmr)
• Francis, G.W. et al., Magn. Reson. Chem., 1998, 36, 769-772, (pmr, cmr, Frangulins, Glucofrangulins)
• Aldrich Library of NMR Spectra, 2nd edn., 1983, 2, 91D, (nmr)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, nos. 1265; 1274, (occur)
• Eder, R. et al., Helv. Chim. Acta, 1925, 8, 140, (bibl)
• Hirose, Y. et al., Chem. Pharm. Bull., 1973, 21, 2790, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MQF250
• Kelly, T.R. et al., J.O.C., 1983, 48, 3573, (isol)
• Sigma-Aldrich Library of Stains, Dyes and Indicators, 298
• Banville, J. et al., Can. J. Chem., 1974, 52, 80, (synth, uv, ir, pmr)
• Anderson, J.A. et al., Phytochemistry, 1986, 25, 1115, (biosynth)
• Wang, E.-C. et al., Heterocycles, 1996, 43, 969, (isol, uv, ir, pmr, cmr, ms)
• Ahmed, S.A. et al., Chem. Comm., 1987, 883, (synth)
• Hassall, C.H. et al., J.C.S. Perkin 1, 1973, 2853, (synth, derivs)
• Coskun, M. et al., Phytochemistry, 1990, 29, 2018, (cd, pmr, cmr)
• Cole, R.J. et al., Handbook of Toxic Fungal Metabolites, Academic Press, New York, 1981, 684