物质信息
ID:449334
名称和标识
IUPAC标准名
(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
别名
GriseofulvinCurling factorIdifulvinAmudaneFulvicinFulcinLikudenGrisovinGrifulvinGrisactinGricinNorofulvin
IUPAC传统名
(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Trichophyton interdigitalis
activity against: Trichophyton rubrum
Trichophyton tonsurans
Trichophyton crateriform
Trichophyton schoenleini
Microsporum canis
Microsporum gypseum
Trichophyton megnini
Trichophyton verrucosum
Trichophyton sulphureum
Trichophyton gallinae
Epidermophyton floccosum.
Antifungal agent against
Trichophyton mentagrophytes
Microsporum audouini
生物来源
Metab. of Penicillium griseofulvum
药理学性质
生物活性机理
Binds tightly to new keratin which becomes highly resistant to fungal invasions
描述信息
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分子图谱
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参考文献
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• Puttaraja, N.K.A. et al., J. Crystallogr. Spectrosc. Res., 1982, 12, 415, (cryst struct)
• Oda, T. et al., Chem. Pharm. Bull., 1983, 31, 934, (synth, derivs)
• Pirrung, M.C. et al., J.A.C.S., 1991, 113, 8561, (synth)
• McMaster, W.J. et al., J.C.S., 1960, 4628, (Dehydrogriseofulvin, Dechlorogriseofulvic acid)
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• Hassan, M.A. et al., Anal. Profiles Drug Subst., 1980, 9, 583, (rev)
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• Cole, R.J. et al., Handbook of Toxic Fungal Metabolites, Academic Press, New York, 1981, 857; 862
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 321D, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1309B, (nmr)
• Townley, E.R., Anal. Profiles Drug Subst., 1979, 8, 219, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 323
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• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, GKE000
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• Brown, W.A.C. et al., J.C.S., 1963, 1050, (cryst struct)
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• Kingston, D.G.I. et al., Phytochemistry, 1976, 15, 1037, (deriv)
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• Pesticide Manual, 9th edn., 1991, No. 6970
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• IARC Monog., 1976, 10, 153; Suppl. 7, 391, (rev, tox)
• Sato, Y. et al., Tet. Lett., 1976, 3971, (cmr, biosynth)
• Hussain, S.A., Diss. Abstr. Int., B, 1986, 47, 2394