物质信息
ID:449232
名称和标识
别名
KetasIbudilast
IUPAC标准名
2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
IUPAC传统名
2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiallergic
Bronchodilator
Neuroprotective
Cerebral vasodilator
药理学性质
生物活性机理
Bronchodilator
Vasodilator
Lowers Ca 2+ deposition in soft tissues
Phosphodiesterase inhibitor
描述信息
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分子图谱
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参考文献
• Nagai, H. et al., Jpn. J. Pharmacol., 1983, 33, 1215, (pharmacol)
• Izumi, Y. et al., Arzneim.-Forsch., 1990, 40, 1300
• Japan. Pat., 1977, Kyorin Pharm, 77 14 799; CA, 87, 53282w, (synth, pharmacol)
• Yasui, M. et al., J. Int. Med. Res., 1990, 18, 415, (pharmacol)
• Ohashi, M. et al., Int. Arch. Allergy Appl. Immunol., 1993, 101, 288, (pharmacol)
• Souness, J.E. et al., Br. J. Pharmacol., 1994, 111, 1081, (pharmacol)
• Mue, S. et al., Arch. Int. Pharmacodyn. Ther., 1986, 283, 153, (pharmacol)
• Ger. Pat., 1973, Kyorin Pharm, 2 315 801; CA, 80, 14923s, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1140