物质信息
ID:449192
名称和标识
IUPAC标准名
2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
别名
PrandinNovoNormRepaglinide
IUPAC传统名
2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antihyperglycaemic agent used in the treatment of type II diabetes
药理学性质
生物活性机理
Stimulating the release of insulin from the pancreas by closing ATP-dependent potassium channels in the membrane of the beta cells
描述信息
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分子图谱
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参考文献
• Ger. Pat., 1987, Thomae, 3 522 604; CA, 106, 196260j, (synth)
• Eur. Pat., 1989, 147 850; CA, 104, 5651p
• Verspohl, E.J. et al., J. Pharm. Pharmacol., 1990, 42, 230, (pharmacol)
• Wolffenbuttel, B.H.R. et al., Eur. J. Clin. Pharmacol., 1993, 45, 113, (use)
• Pat. Coop. Treaty (WIPO), 1993, Thomae, 93 00 337; CA, 118, 254759q, (synth, isomers)