物质信息
ID:449151
名称和标识
IUPAC标准名
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
别名
FursemideLasixFrumaxDryptalRusydeFrusemideDiurapidFrusidFrusolTenkafruseFroop
IUPAC传统名
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Diuretic
Used for treatment of cirrhotic patients with ascites.
Used in conjunction with Spironolactone HJR81-N for prophylaxis of hypokalaemia and hepatic encephalopathy or in treatment of hyperaldosteronism
Antihypertensive
药理学性质
生物活性机理
Inhibitor of carbonic anhydrase,
subtype-specific blocker of GABA-A receptors
描述信息
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分子图谱
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参考文献
• Brater, D.C., Annu. Rev. Pharmacol. Toxicol., 1983, 23, 45, (rev, pharmacol)
• Al-Obaid, A.M. et al., Anal. Profiles Drug Subst., 1989, 18, 153, (rev)
• Ponto, L.L.B. et al., Clin. Pharmacokinet., 1990, 18, 460, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 871
• Prandota, J. et al., Eur. J. Drug Metab. Pharmacokinet., 1976, 1, 177, (rev, metab)
• Lamotte, J. et al., Acta Cryst. B, 1978, 34, 1657, (cryst struct)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 2766, (synonyms)
• Du Souich, P. et al., Prog. Pharmacol. Clin. Pharmacol., 1992, 9, 147, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CHJ750
• Sturm, K. et al., Chem. Ber., 1966, 99, 328; 345, (synth, props)
• IARC Monog., 1990, 50, 277, (rev, tox)
• Stanker, L.H. et al., J. Agric. Food Chem., 1996, 44, 2455-2459, (occur)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 41C, (nmr)
• Rupp, W. et al., Arch. Int. Pharmacodyn. Ther., Suppl., 1980, 119, (rev, pharmacol)
• Aspects of Diuretic Therapy with Furosemide: an Update, Wells Medical, 1993, (book)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 591A, (ir)
• Benet, L.Z., J. Pharmacokinet. Biopharm., 1979, 7, 1, (rev)