物质信息
ID:449148
名称和标识
IUPAC标准名
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
别名
DiflucanElazorTriflucanBiozoleneFluconazoleFungata
IUPAC传统名
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Inhibitor of fungal cytochrome P450 enzyme 14alpha-demethylase
产品相关信息
应用领域
Effective in single oral dose against vaginal candidiasis
Not active against Aspergillus
Antifungal agent
Prophylactic treatment for AIDS patients
描述信息
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分子图谱
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参考文献
• Goa, K.L. et al., Drugs, 1995, 50, 658, (rev, pharmacokinet)
• Cobos Garcia, F.J. et al., Farm. Clin., 1991, 8, 423, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3349, (synonyms)
• U.K. Pat., 1982, Pfizer, 2 099 818; CA, 99, 38467q, (synth, pharmacol)
• Urbak, S.F. et al., Ophthalmologica, 1994, 208, 147, (use, rev)
• Morck, H., Pharm. Ztg., 1991, 136, 56; 60, (rev)
• Pat. Coop. Treaty (WIPO), 1997, Pfizer, 97 28 169; CA, 127, 220800s, (fosfluconazole, synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 378
• Fluconazole, (Eds., Powderly, W.G. et al), Marius Press, 1992, (book)
• Morita, K. et al., Chem. Pharm. Bull., 1992, 40, 1247, (pharmacol)
• Grant, S.M. et al., Drugs, 1990, 39, 877, (rev)