物质信息
ID:449146
名称和标识
IUPAC标准名
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
别名
FamvirFamciclovir
IUPAC传统名
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Undergoes rapid biotransformation to penciclovir
that, in turn, is converted to penciclovir triphosphate by cellular (human) kinases
Consequently, herpes viral DNA synthesis and replication are selectively inhibited.
Guanine analogue
Prodrug of penciclovir with improved oral bioavailability
Penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate
In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form
产品相关信息
应用领域
Antiviral drug
Used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles).
描述信息
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分子图谱
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参考文献
• Vere Hodge, R.A. et al., Antimicrob. Agents Chemother., 1989, 33, 1765, (synth, pharmacokinet)
• Cirelli, R. et al., Antiviral Res., 1996, 29, 141, (rev, pharmacol)
• Vere Hodge, R.A., Antiviral Chem. Chemother., 1993, 4, 67, (rev)
• Genn, G.R. et al., J. Med. Chem., 1989, 32, 1738, (synth)
• Harnden, M.R. et al., Nucleosides Nucleotides, 1990, 9, 499, (cryst struct)
• Vere Hodge, R.A. et al., Chirality, 1993, 5, 577, (metab)
• Filer, C.W. et al., Xenobiotica, 1994, 24, 357, (metab, pharmacokinet, human)
• Brand, B. et al., Tetrahedron, 1999, 55, 5239-5252, (synth, pmr, cmr)
• Eur. Pat., 1986, Beecham, 182 024; CA, 105, 133669, (synth, pmr, pharmacol)
• Winton, C.F. et al., Anal. Proc. (London), 1990, 27, 181, (hplc)
• Freer, R. et al., Tetrahedron, 2000, 56, 4589-4595, (synth, pmr, cmr)
• Sutton, D. et al., Antiviral Res., 1993, 4, 37, (rev)