物质信息

ID:4378

名称和标识
别名
D-camptothecin(+)-camptothecin(s)-(+)-camptothecinCamptothecin20(S)-Camptothecin21,22-Secocamptothecin-21-oic acid lactone(s)-camptothecinCPT(+)-camptothecineCamptothecine
IUPAC传统名
camptothecin
IUPAC标准名
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
数据登录号
CAS号
7689-03-4
PubChem CID
24360
PubChem SID
46507644
化合物性质
理化性质
疏水性(logP)
1.74 [HANSCH,C ET AL. (1995)]
描述信息
Drug Groups
experimental
Description
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. [PubChem]
Indication
Investigated for the treatment of cancer.
Pharmacology
Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.
Toxicity
Acute oral toxicity (LD50) in mouse: 50.1 mg/kg
Affected Organisms
Humans and other mammals
References
• Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4. [Pubmed]
• Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8. [Pubmed]
External Links
• [Wikipedia]
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参考文献
• Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8. Pubmed
• Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4. Pubmed
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