Drug Groups

approved

Description

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

Indication

Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

Pharmacology

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.

Toxicity

Oral, rat: LD₅₀ = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.

Affected Organisms

Biotransformation

35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).

Absorption

Well absorbed from the GI tract following oral administration.

Half Life

5-10 hours in patients with normal renal function

Protein Binding

No known binding

References

External Links