物质信息
ID:421
名称和标识
别名
gadoversetamideGadoversetamideGadoversetamide [USAN:INN:BAN]
商标名
OptiMARK
IUPAC标准名
gadolinium(3+) ion 2-[bis({2-[(carboxylatomethyl)({[(2-methoxyethyl)carbamoyl]methyl})amino]ethyl})amino]acetate
IUPAC传统名
gadolinium(3+) 2-[bis({2-[(carboxylatomethyl)({[(2-methoxyethyl)carbamoyl]methyl})amino]ethyl})amino]acetate
化合物性质
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描述信息
Drug Groups
approved; investigational
Description
Gadoversetamide is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver. It is marketed under the trade name OptiMARK.
Indication
Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
Affected Organisms
Humans and other mammals
Biotransformation
None detected
Half Life
Distribution 13.3 ± 6.8 (mean) minutes, elimination 103.6 ± 19.5 (mean) minutes.
Elimination
The mean cumulative urinary excretion of gadoversetamide at 72 hours was approximately 93.5% for renal impaired patients and 95.8% for subjects with normal renal function
Distribution
* 162 ± 25 mL/kg [normal subjects]
Clearance
* 72 +/- 16.3 mL/hr/kg [healthy]
External Links
分子图谱
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参考文献
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