物质信息
ID:399203
名称和标识
IUPAC标准名
methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
IUPAC传统名
methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-(morpholin-4-yl)pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
别名
4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl EsterWYE 354 WYE-354
数据登录号
CAS号
描述信息
A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and
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参考文献
• Dormind-Meuwly, A. et al.: Biochem. Biophys. Res. Comm., 407, 714 (2009)
• Zask, A. et al.: J. Med. Chem., 52, 5-13 (2009)
• Yu, K. et al.: Cancer Res., 69, 6232 (2009)