物质信息
ID:399186
名称和标识
IUPAC传统名
zileuton
IUPAC标准名
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
别名
ZileutonZYFLOLeutrolAbbott 64077N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyureaA-64077
数据登录号
CAS号
描述信息
An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.
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参考文献
• Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1991)
• McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)
• Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991)