物质信息
ID:395420
名称和标识
IUPAC标准名
3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
IUPAC传统名
ponatinib
别名
AP 245343-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamidePonatinib
数据登录号
CAS号
化合物性质
理化性质
熔点
>160°C (dec.)
溶解度
DMSO
Methanol
外观
Pale Yellow Solid
安全信息
MSDS下载
保存条件
Amber Vial, Refrigerator, Under inert atmosphere
产品相关信息
质检报告
描述信息
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.
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参考文献
• Quintas-Cardama, A., et al.: Blood, 2009, 113, 1619 (2005)
• Weisberg, E., et al.: Cancer Cell, 7, 129 (2005)
• Zhou, T., et al.: Chem. Biol. Drug Des., 70, 171 (2005)