物质信息
ID:393194
名称和标识
别名
NitisinoneNTBCOrfadinNitisone2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedioneSC 0735
IUPAC标准名
2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
IUPAC传统名
nitisone
数据登录号
CAS号
化合物性质
安全信息
MSDS下载
保存条件
-20°C Freezer
理化性质
溶解度
Chloroform
Ethyl Acetate
熔点
129-131°C
外观
Light Brown Solid
产品相关信息
质检报告
描述信息
Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
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参考文献
• Lindstedt, S., et al.: Lancet, 340, 813 (1992)
• Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1992)
• Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1992)