物质信息
ID:389449
名称和标识
IUPAC标准名
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
IUPAC传统名
leflunomide
别名
LeflunomideLeflunomidum5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]Leflunomida5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
数据登录号
CAS号
化合物性质
理化性质
熔点
153-156°C
溶解度
Dichloromethane
Ether
Methanol
Ethyl Acetate
外观
Off White Solid
产品相关信息
质检报告
安全信息
MSDS下载
保存条件
-20°C Freezer
描述信息
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical
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参考文献
• Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008)
• Vrenken, T., et al.: J. Hepatol., 49, 799 (2008)
• Davies, M., et al.: J. Med. Chem., 52, 2683 (2008)