物质信息
ID:388796
名称和标识
IUPAC传统名
irofulven
IUPAC标准名
(6'R)-6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethyl-6',7'-dihydrospiro[cyclopropane-1,5'-indene]-7'-one
别名
(-)-(Hydroxymethyl)acylfulveneMGI 114(6'R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one(-)-IrofulvenHMAFNSC 683863(R)-Irofulven
数据登录号
CAS号
描述信息
Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.
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参考文献
• Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (1997)
• Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997)
• Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (1997)