物质信息
ID:383965
名称和标识
IUPAC传统名
vaniqa hydrate hydrochloride
IUPAC标准名
2,5-diamino-2-(difluoromethyl)pentanoic acid hydrate hydrochloride
别名
DFMODL-2-(Difluoromethyl)ornithineα,δ-Diamino-α-(difluoromethyl)valeric Acidα-(Difluoromethyl)-DL-ornithineα-(Difluoromethyl)ornithineElfornithine2-(Difluoromethyl)ornithineDL-α-(Difluoromethyl)ornithineMDL 71782AOrnidylRFI 71782RMI 717822-(Difluoromethyl)-DL-ornithine Hydrochloride HydrateMDL 71782Eflornithine Hydrochloride Monohydrate
数据登录号
CAS号
描述信息
Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.
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参考文献
• Meyskens, F.L., et al.: Clin. Cancer Res., 5, 945 (1980)
• Bacchi, C.J., et al.: Science, 210, 332 (1980)
• Haegele, K.D., et al.: Clin. Pharmacol. Ther., 30, 210 (1980)