物质信息
ID:380201
名称和标识
IUPAC传统名
colchicine
IUPAC标准名
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
别名
Condylon(S)-Colchicine >95%N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamideColchisolColsaloidColchineosColcinNSC 757(-)-Colchicine
数据登录号
CAS号
化合物性质
产品相关信息
质检报告
理化性质
熔点
150-152°C
外观
Yellow Solid
溶解度
Ethyl Acetate
Chloroform
Methanol
安全信息
MSDS下载
保存条件
-20°C Freezer
描述信息
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa
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参考文献
• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)