物质信息
ID:376676
名称和标识
IUPAC标准名
3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
IUPAC传统名
3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione
别名
Ro 31-75493-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dioneRo 31-7549/001Bisindolylmaleimide VIII
数据登录号
CAS号
描述信息
It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
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参考文献
• Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998)
• Wiley, S., et al.: Immunity, 3, 673 (1998)
• MacFarlane, M., et al.: Biochem. J., 348, 93 (1998)