物质信息
ID:373281
名称和标识
IUPAC传统名
4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
IUPAC标准名
4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
别名
Aloisine A RP1074-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolRP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
数据登录号
CAS号
描述信息
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,
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参考文献
• Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2003)
• Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003)
• Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2003)