物质信息
ID:358746
名称和标识
IUPAC标准名
3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
别名
tretinoinATRAVitamin A acidRetinoic acidall-trans-Retinoic acid
IUPAC传统名
isotretinoin
化合物性质
产品相关信息
杂质
≤0.002% heavy metals
Empirical Formula (Hill Notation)
C20H28O2
燃烧残渣
≤0.1% (as SO4)
干燥失重
≤0.5% loss on drying
纯度
≥98.0% (HPLC)
安全信息
欧盟危险性物质标志
环境危害性 (N)
有害性 (Xn)GHS警示性声明
P273
安全公开号
61
GHS危险声明
H302-H411
德国WGK号
2
GHS危险品标识
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
RTECS编号
VH6475000
危险公开号
22-51/53
GHS警示词
Warning
MSDS下载
保存温度
2-8°C
药理学性质
相关基因信息
human ... RARA(5914), RARB(5915), RARG(5916)
理化性质
熔点
180-181 °C(lit.)
182-186 °C
描述信息
Other Notes
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
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