物质信息
ID:357501
名称和标识
IUPAC传统名
wortmannin
IUPAC标准名
(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl acetate
别名
KY 12420Wortmannin
化合物性质
安全信息
GHS警示性声明
P260-P264-P280-P284-P302+P350-P310
RID/ADR
UN 3462 6.1/PG 1
RTECS编号
CB9641000
保存温度
2-8°C
危险公开号
26/27/28
安全公开号
28-36/37-45
GHS危险声明
H300-H310-H330
欧盟危险性物质标志
剧毒 (T+)个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示词
Danger
MSDS下载
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
联合国危险货物编号
3462
德国WGK号
3
联合国危险货物包装类别(PG)
1
联合国危险货物等级
6.1
产品相关信息
Empirical Formula (Hill Notation)
C23H24O8
纯度
≥98.0% (TLC)
描述信息
Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
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