物质信息
ID:354871
名称和标识
IUPAC传统名
brefeldin A
IUPAC标准名
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
别名
γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactoneCyaneinBrefeldin ADecumbinBFAAscotoxin
化合物性质
理化性质
熔点
200-205 °C
溶解度
methanol: soluble10 mg/mL, clear, colorless to faintly yellow
安全信息
GHS警示词
Danger
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
保存温度
2-8°C
GHS警示性声明
P301+P310
联合国危险货物等级
6.1
GHS危险声明
H301
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS编号
GY8410000
RID/ADR
UN 2811 6.1/PG 3
危险公开号
22
联合国危险货物编号
2811
联合国危险货物包装类别(PG)
3
德国WGK号
3
MSDS下载
欧盟危险性物质标志
有害性 (Xn)产品相关信息
生物来源
from Penicillium brefeldianum
Empirical Formula (Hill Notation)
C16H24O4
纯度
≥99.0% (TLC)
描述信息
Other Notes
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
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